Reliable Dose Verification for Critical Applications
In radiation processing, accuracy is non-negotiable. Whether you’re sterilizing medical devices, validating food irradiation, modifying polymers, or conducting high-dose research, reliable absorbed dose measurement is essential. But with varying radiation sources, complex geometries, and critical compliance requirements, consistency and traceability can be challenging.
Our smart alanine dosimetry solution, based on Electron Paramagnetic Resonance (EPR), offers a proven, ISO/ASTM 51607:2013-compliant method to quantify doses from 1 Gy to 200 kGy. Using high-stability α-alanine pellets, the system ensures reproducible, energy-independent results — ideal for audit trails, calibration, and dose mapping across industrial and scientific applications.
Alanine dosimetry is widely recognized by international standards bodies and leading research organizations as a reference method for high-dose radiation measurement. Its non-destructive, stable signal enables delayed readout and long-term archiving without loss of accuracy, making it a trusted solution for regulatory compliance, retrospective validation, and continuous quality assurance across industries.
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Purpose-Built for Accurate Dose Verification
The Alanine Dosimeter is a modular, scalable solution for precise radiation dose verification, purpose-built around the principles of Electron Paramagnetic Resonance (EPR). At its core lies the SPINSCAN benchtop spectrometer — a high-precision EPR platform optimized for analyzing irradiated α-alanine pellets across a broad dose range. Whether deployed as a fully automated system with an integrated autosampler or as a manual station with single-pellet loading, the Alanine Dosimeter adapts to your workflow, throughput, and budget.
Why Alanine-EPR Dosimetry?
Unlike traditional film, TLD, or radiochromic dosimeters, alanine-based EPR provides:
- Energy-independent, linear dose response from 1 Gy to 200 kGy
- Stable signal with long-term re-readability and no signal fading
- Non-destructive measurement and minimal environmental sensitivity
- Compliance with ISO/ASTM 51607:2013 global standards
Two Configurations, One Core Platform
The Alanine Dosimeter is available in two configurations — both built around the same SPINSCAN EPR spectrometer and supported by a unified software platform:
- Automated Version: Equipped with a 50/100-position autosampler, ideal for high-throughput dosimetry, industrial QA, and calibration campaigns.
- Manual Version: Compact and cost-effective setup for research, low-volume workflows, or standalone validation tasks — with full upgrade potential.
Designed Around Real-World Needs
Both system types incorporate precision-engineered holders, autogain control, ruby-based reference verification, and guided calibration workflows. The result is a highly stable, reproducible measurement process suitable for regulated and research environments alike.
Ideal for Diverse Applications
This flexible dosimetric platform is trusted across multiple domains:
- Medical device sterilization – ensures accurate validation of irradiation cycles
- Pharmaceutical and cosmetic processing – supports product safety and compliance
- Food irradiation – delivers quantitative dose monitoring for process QA
- Polymer and material modification – ideal for high-dose research applications
- Medical physics – supports beam QA, dose mapping, and radiobiological studies
Scientific Foundation and Measurement Principle
The Alanine Dosimeter operates by detecting stable free radicals generated in α-alanine under ionizing radiation. The system’s SPINSCAN spectrometer captures a reproducible multi-peak EPR spectrum whose intensity is proportional to the absorbed dose. This signal remains consistent across various irradiation types — including electron beams, gamma rays, and X-rays — making the method field-agnostic and reliable in complex environments.
Two Configurations. Same EPR Core.
The Alanine Dosimeter is available in two scalable configurations — both built on the same SPINSCAN EPR spectrometer and using a unified software platform:
- Automated System: Includes a precision autosampler for 50 or 100 pellets, designed for continuous operation in industrial settings with minimal user intervention.
- Manual System: A streamlined benchtop configuration ideal for QA labs, academic research, and environments requiring hands-on control or constrained by space and budget. Dosimeters are manually inserted into a fixed holder for direct analysis.
Automation and Repeatability
In the automated configuration, a precision-engineered autosampler simplifies repetitive measurements and enhances batch consistency. Fixed-position holders ensure optimal pellet alignment for every scan. This setup supports:
- Calibration curve creation and verification
- Absorbed dose evaluation
- Long-run dose mapping campaigns
Software Suite for End-to-End Control
Both configurations are powered by the same intuitive software platform that provides complete data lifecycle management — from sample identification and scheduling to dose reporting and audit-traceable archival. Key features include:
- Autogain tuning for optimal signal resolution
- Integrated ruby reference for calibration stability
- Environmental compensation for temperature and humidity
- Minimal training required thanks to guided workflows
Trusted Method for Long-Term Quality
Unlike destructive or degradable alternatives, EPR-based alanine dosimetry allows for long-term sample storage and reanalysis. Its traceability and repeatability make it particularly effective for audits, regulatory compliance, and dose validation in high-reliability environments.
Flexible Across Industries
The Alanine Dosimeter is widely used in:
- Healthcare & medical sterilization centers
- Food processing and irradiation QA lines
- Environmental radiation exposure analysis
- Academic and industrial research labs
Its compact size, modular architecture, and configuration options allow for seamless integration in both laboratory and production settings — with the flexibility to grow as operational demands evolve.
Designed for Industrial Precision
- Available in manual and automated configurations
- Full compliance with ISO/ASTM 51607:2013
- Energy-independent dose measurements from 1 Gy to 200 kGy
- Integrated autosampler for 50/100 pellet automation (optional)
- Non-destructive and repeatable alanine readout
- Suitable for electron, gamma, and X-ray sources
- Compact design for lab or production environments
- Automated calibration and dose mapping workflow
- Traceable, audit-ready measurement archive
3D View
Comprehensive Software for Automated Dosimetry
The Alanine Dosimeter is powered by an advanced, purpose-built software platform that orchestrates every stage of the dosimetric process — from initial calibration to final reporting. Far more than a control interface, the software acts as the digital backbone of the system, ensuring accuracy, traceability, and efficiency throughout the entire measurement workflow.
Its core functionality covers a complete measurement lifecycle: managing sample identification and scheduling, automating dose acquisition and analysis, verifying calibration curves, and archiving structured results for audit-ready compliance. The software is built to meet the rigorous demands of users in industrial radiation processing, pharmaceutical sterilization, medical device validation, and research laboratories.
By reducing operator workload and standardizing measurement procedures, the system eliminates common sources of human error while increasing repeatability across batches. Whether running high-throughput campaigns with 100-dose batches or executing precise single-point calibrations, the software adapts dynamically to each task. All actions are logged, results are traceable, and every step aligns with ISO/ASTM protocols — making it a trusted tool for regulated environments where documentation and metrological confidence are critical.
Automated Measurement Workflow
| Calibration Curve Management
|
Dose Evaluation and Correction
| Data Management and Reporting
|
The software also includes features such as autogain optimization for maximum signal resolution, a user-friendly graphical interface that requires no advanced EPR training, and multi-user access management. Together, these capabilities make the Alanine Dosimeter software a central part of the system — ensuring traceable, automated, and high-confidence dose verification across a wide range of applications.
Key features 
Automated Multi-Pellet Measurement
The Alanine Dosimeter can be configured with an optional autosampler capable of handling 50 or 100 pellets in a single session. This feature automates the measurement process, significantly reducing operator workload and improving throughput — ideal for industrial and high-volume QA workflows. With precise dosimeter positioning and batch scripting, the system ensures both speed and reproducibility while maintaining full metrological integrity.
Stable, Non-Destructive EPR Readout
Using α-alanine as the sensing medium, the dosimeter delivers a highly stable EPR signal that remains unchanged over time and allows repeated scanning. This non-destructive measurement approach eliminates the need for post-irradiation processing and ensures that results remain valid for audit, verification, or long-term traceability.
Energy-Independent Dose Response
The alanine-EPR method offers a consistent response across different radiation types and energy levels, including gamma, electron beam, and X-ray sources. This makes the Alanine Dosimeter ideal for facilities with mixed-field environments, where uniformity and accuracy are critical for dose validation and regulatory compliance.
Integrated Calibration and Curve Management
The system includes built-in calibration curve management, allowing users to generate, verify, and apply dose-response curves using certified reference dosimeters. This feature ensures traceable, standardized results across facilities and campaigns — and reduces calibration errors during daily operations.
Regulatory-Grade Metrological Accuracy
Compliant with ISO/ASTM 51607:2013, the Alanine Dosimeter provides metrological-quality readings with high repeatability (<1% variation). Environmental compensation algorithms, ruby reference verification, and autogain tuning maintain signal integrity under varying lab conditions, delivering consistent results from 1 Gy to 200 kGy.
Compact, Scalable System Architecture
Designed for seamless integration into both laboratory and production environments, the system occupies minimal bench space while offering full-scale functionality. Whether used in a GMP-compliant QA lab or an R&D setting, the Alanine Dosimeter scales to meet operational needs without compromising precision or usability.
Automated Multi-Pellet Measurement
The Alanine Dosimeter can be configured with an optional autosampler capable of handling 50 or 100 pellets in a single session. This feature automates the measurement process, significantly reducing operator workload and improving throughput — ideal for industrial and high-volume QA workflows. With precise dosimeter positioning and batch scripting, the system ensures both speed and reproducibility while maintaining full metrological integrity.
Stable, Non-Destructive EPR Readout
Using α-alanine as the sensing medium, the dosimeter delivers a highly stable EPR signal that remains unchanged over time and allows repeated scanning. This non-destructive measurement approach eliminates the need for post-irradiation processing and ensures that results remain valid for audit, verification, or long-term traceability.
Energy-Independent Dose Response
The alanine-EPR method offers a consistent response across different radiation types and energy levels, including gamma, electron beam, and X-ray sources. This makes the Alanine Dosimeter ideal for facilities with mixed-field environments, where uniformity and accuracy are critical for dose validation and regulatory compliance.
Integrated Calibration and Curve Management
The system includes built-in calibration curve management, allowing users to generate, verify, and apply dose-response curves using certified reference dosimeters. This feature ensures traceable, standardized results across facilities and campaigns — and reduces calibration errors during daily operations.
Regulatory-Grade Metrological Accuracy
Compliant with ISO/ASTM 51607:2013, the Alanine Dosimeter provides metrological-quality readings with high repeatability (<1% variation). Environmental compensation algorithms, ruby reference verification, and autogain tuning maintain signal integrity under varying lab conditions, delivering consistent results from 1 Gy to 200 kGy.
Compact, Scalable System Architecture
Designed for seamless integration into both laboratory and production environments, the system occupies minimal bench space while offering full-scale functionality. Whether used in a GMP-compliant QA lab or an R&D setting, the Alanine Dosimeter scales to meet operational needs without compromising precision or usability.
No chemical processing, no daily recalibration — the system is built for durability, with self-checks and long-term mechanical stability.
Equally suited to single-unit labs or multi-line production, the system scales with your needs — from small-batch QA to facility-wide dose monitoring.
Developed in collaboration with radiation laboratories, sterilization professionals, and research users — the system is field-proven, not just lab-tested.
Technical data
Technical details
| Sensitivity | 8×109 spins / 0,1 mT |
| Resolution | 0,005 mT |
| Maximum magnetic field | 0,7 T |
| Sweep width | 10-4—0,65T |
| Operating Frequency | X-band |
| Microwave power | 0,01—200 mW |
| Magnetic field modulation | 10—250 kHz |
| MW bridge and cavity tuning | Automatic |
| Cavity | TE102 |
| Q unloaded | 5000 |
| Amplitude resolution | 24 bit |
Dimensions
| Overall dimensions | |
|---|---|
| Width | 470 mm |
| Length | 380 mm |
| Height | 260 mm |
| Weight (maximum) | 45 kg |
|---|
Technical details
| Sensitivity | 8×109 spins / 0,1 mT |
| Resolution | 0,005 mT |
| Maximum magnetic field | 0,7 T |
| Sweep width | 10-4—0,65T |
| Operating Frequency | X-band |
| Microwave power | 0,01—200 mW |
| Magnetic field modulation | 10—250 kHz |
| MW bridge and cavity tuning | Automatic |
| Cavity | TE102 |
| Q unloaded | 5000 |
| Amplitude resolution | 24 bit |
Dimensions
| Overall dimensions | |
|---|---|
| Width | 18,5″ |
| Length | 14.9″ |
| Height | 10.2″ |
| Weight (maximum) | 99.2 lbs |
|---|
Product Videos
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Quote of the Day:
Alanine-based ionizing radiation dosimetry is firmly woven into the fabric of high-dose radiation metrology. Because of its superior attributes, alanine dosimetry was recognized at an early stage to be of great importance to National Measurement Institute (NMI) services and programs.
S. L. Cooper
National Institute of Standards and Technology
publication Сo-author
Why Alanine Dosimetry
Alanine dosimetry has long been recognized as a gold standard for high-accuracy radiation dose measurement. Based on the formation of stable free radicals in α-alanine upon irradiation, this method provides a direct, quantitative signal using Electron Paramagnetic Resonance (EPR). Unlike dosimeters that degrade over time or require chemical processing, alanine maintains its signal integrity indefinitely, allowing repeat measurements and long-term traceability — a critical advantage for audits, retrospective analysis, and regulatory validation..
One of the method’s defining strengths is its energy independence. The EPR signal produced by irradiated alanine is consistent across gamma, X-ray, and electron beam sources, making it ideal for facilities operating in mixed-field environments. Its wide linear dose range — from 1 Gy to 200 kGy — enables a single dosimetric platform to support both low-dose therapeutic studies and high-dose sterilization control. This universality simplifies calibration, reduces operational complexity, and ensures reliable results across use cases.
Alanine dosimetry is also fully aligned with international standards, including ISO/ASTM 51607:2013. It is widely accepted by regulatory bodies and scientific institutions as a reference method, and is routinely used for dose validation in radiation processing of medical devices, food, pharmaceuticals, and materials. When paired with an automated EPR system like the Alanine Dosimeter, it delivers unmatched consistency, reproducibility, and compliance — without compromise.
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